PSORIASIS

Diagnosis: PSORIASIS

Case submitted by Dr.Azeem Alam Khan to the dermRounds community.

Clinical Presentation

Clinical photograph(s) submitted for peer review and discussion.

Clinical History

Submitted by Dr.Azeem Alam Khan. Originally posted June 10, 2009.

Treatment

See case discussion.

Differential Diagnosis

• Eczema/atopic dermatitis • Seborrheic dermatitis • Lichen planus • Pityriasis rosea • Tinea corporis • Secondary syphilis • Mycosis fungoides • Nummular eczema

Key Learnings

• Immune-mediated disease driven by Th17/IL-23 axis • Auspitz sign: pinpoint bleeding when scale is removed (dilated capillaries in dermal papillae) • Koebner phenomenon: lesions develop at sites of trauma • Nail involvement in ~50%: pitting, oil drop sign, onycholysis, subungual hyperkeratosis • Psoriatic arthritis develops in ~30% — screen regularly (CASPAR criteria) • Metabolic syndrome, cardiovascular disease, and depression are major comorbidities • Biologic therapy has revolutionized treatment — IL-17 and IL-23 inhibitors achieve PASI 90/100 in many patients • Histology: regular acanthosis, Munro microabscesses, dilated capillaries in dermal papillae, diminished granular layer

Tags: psoriasis, dr.azeem alam khan